The preservation of the overall perisomatic inhibitory input and the ratio of PV+ inhibitory input of neocortical pyramidal cells in epilepsy contrasts to the hippocampal dentate gyrus of temporal lobe epileptic (TLE) patients, where the perisomatic inhibitory input of dentate granule cells has notably increased together with the enhancement of the CB1R+ inhibitory boutons [51] and with the reduction of PV+ cell numbers and ratio of PV+ somatic synapses [45]. Here, CNR1 is linked to epilepsy.