NOTCH1 and T-cell acute lymphoblastic leukemia: NEAT1 was found increased in T-cell acute lymphoblastic leukemia, in which it upregulates NOTCH1 expression via sponging hsa-miR-146b-5p, and in multiple myeloma in which via inhibition of hsa-miR-214 it promotes M2 macrophage polarization by inducing the expression and release of B7-H3, resulting in the activation of JAK2/STAT3 signaling [62,63].