A comparative study of the improving effect of MF therapy, orthosteric and allosteric LH/hCG-R-agonists and their combinations on steroidogenesis and spermatogenesis is very important for developing an optimal strategy for normalizing reproductive functions in T2DM, as well as for increasing the effectiveness of assisted reproductive technology in diabetic pathology. This evidence concerns the gene PLOD1 and type 2 diabetes mellitus.