PLOD1 and type 2 diabetes mellitus: Based on this, it can be assumed that the steroidogenic effects of TP3 may not be so sensitive to inactivating modifications of LH/hCG-R under hyperglycemia and oxidative stress, typical for T2DM, which are believed to be capable of disrupting the maturation of LH/hCG-R and its translocation into the plasma membrane.