When comparing the COVID-19 to the H1N1 group, statistically increased tissue immunoexpression of ACE-2 (p = 0.0005), CD44v6 (p < 0.0001), IL-4 (p < 0.0001), and α-SMA (p < 0.0001) were observed in the former. The gene discussed is IL4; the disease is COVID-19.