Based on proteomic data and their possible relationship with astrocytes in the disease, BAG3, HSP90AA1, HSP90AB1, HSPA4L, and FKBP4 were selected for further immunofluorescence and Western blot (WB) analyses to assess the relevance of heat shock proteins (HSPs) in AD [46]. This evidence concerns the gene HSP90AB1 and Alzheimer disease.