CA12 and glioblastoma: However, this effect was more pronounced after ACZ stimulation, which might be based on the fact that ACZ is much more potent than BRZ to modulate mitochondrial activity, since ACZ inhibits CA2 and other CA family members, such as CA9, CA12 which are expressed in both GBM cell lines independent of CA2 expression (Figure S2) and are involved in the mitochondrial metabolism.