FCGR3A and neoplasm: For instance, a TriKE named 161,533 TriKE, consisting of one scFv against CD16, another scFv against tumor antigen (TA) CD33, and an IL-15 in between as a linker, effectively triggers NK recognition of neoplastic mast cells, which is normally resistant to NK-mediated immunity, as well as augments NK cell activation, degranulation and inflammatory cytokine production [159,160].