TGFB1 and neoplasm: TGF-β is largely produced by tumor cells, regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) in the TME, and it has a strong association with poor prognosis in lung carcinoma [77], pancreatic cancer [78], gastric cancer [79], colorectal cancer [80], and hepatocellular carcinoma [81].