Vimentin is an intermediate filament participating in cell adhesion, migration, survival, and epithelial-to-mesenchymal transition [53] VIM was suggested to act as a renal cell carcinoma oncogene (regulated by miRNA-138) in clear cell renal cell carcinoma, however, its role in the pathogenesis of ccpRCC remains unclear and requires further examination [54]. This evidence concerns the gene VIM and clear cell renal carcinoma.