It is important to emphasize genes upregulated in both cell lines, namely CATULIN, L1 cell adhesion molecule (L1CAM), FOXM1, SERPINE1, neuropilin-1 (NRP1), EPHA2, tenascin-C (TNC), and caveolin-1 (CAV1), suggesting a common mechanism of invasion in HNSCC. This evidence concerns the gene L1CAM and head and neck squamous cell carcinoma.