It has also been shown that catulin is highly expressed in malignant melanoma cells and is a key factor in tumor development, invasion, and metastasis due to the downregulation of E-cadherin and the upregulation of mesenchymal markers such as N-cadherin, Snail/Slug, and the matrix metalloproteinases 2 and 9 [27], as well as contributing to chemoresistance by the activation of NF-κB and AP-1 and the phosphorylation of ERK [28]. The gene discussed is CDH1; the disease is neoplasm.