Mutations in Insulin Like Growth Factor Receptor 2 (IGF2R) and Deleted in Colorectal Cancer (DCC) genes were reported to be strikingly more frequent among mucosal as compared with cutaneous melanomas, accounting for nearly 32% of patients in the study by Iida et al. According to the Tumor Cancer Genome Atlas (TCGA) database, such mutations are quite uncommon in other types of solid tumors, thus confirming the peculiar and unique genetic background of mucosal melanomas [12]. This evidence concerns the gene IGF2R and cutaneous melanoma.