Other less commonly described mutations in mucosal melanomas are TP53 (8.9%), sprout-related EVH1 domain containing protein 1 (SPRED1) (7%), ATP dependent helicase (ATRX) (6%), and Chromodomain Helicase DNA Binding Protein 8 (CHD8) (4%) [10,11,12]. The gene discussed is SPRED1; the disease is mucositis.