MMP14 and cancer: This latter mechanism also illustrates the central importance of MMP-14 as the master MMP in particular in invadopodia of invading cancer cells: Two MMP-14 molecules dimerize on the plasma membrane, with the catalytic center of one MMP-14 binding the N-terminal domain of a TIMP-2, which can interact with its C-terminus with the hemopexin domain of proMMP-2 [123].