SEC63 and cancer: Related diseases that arise from mutations or the overabundance of these proteins are diverse and include different types of cancer (Sec61γ, Sec62, Sec63), autosomal dominant polycystic liver disease (Sec61β, Sec63) as well as common variable immunodeficiency, neutropenia, and autosomal dominant tubulointerstitial kidney disease (Sec61α) [276,283,403,404,405,406,407,408].