NLRP3 and ischemia reperfusion injury: Therefore, some studies usually reduce brain damage by reducing the pyrolysis caused by NLRP3, e.g., hispidulin, astilbin, and adiponectin peptides inhibit NLRP3-mediated pyrolysis by regulating the AMPK/GSK3β signaling pathway, improve the neurological symptoms after ischemia-reperfusion injury in rats, and reduce the infarct size and cerebral edema [129,130,131].