When studying the relationship between mitochondrial ribosomal protein L13 (MRPL13) and CLDN1 in liver cancer patients, Lee YK et al. [36] found that in the MRPL13–low group, CLDN1 expression negatively correlated with pyruvate dehydrogenase B (PDHB) expression and the ratio of LDHB/LDHA, which suggested a metabolic change to glycolysis. The gene discussed is PDHB; the disease is liver cancer.