A study using male C57BL/6 mice, including wild type, Cysltr1−/− and Cysltr2−/−, implanted with Matrigel plugs or subcutaneously injected with Lewis lung carcinoma cells demonstrated the important role of CysLT2R in regulating tumor angiogenesis, metastasis and endothelial cell dysregulation [90]. This evidence concerns the gene CYSLTR2 and neoplasm.