CYSLTR1 and squamous cell carcinoma: LTC4 mediated the second wave of Rac1 activation and cell migration; treatment with 5-LO inhibitors (AA861 and BU-4664L) or CysLT1R antagonists (MK571 and montelukast), as well as knockdown of CysLT1R, suppressed cell migration of A431 cells, an epidermoid carcinoma cell line, through downregulating EGF-induced expression of T cell lymphoma invasion and metastasis-inducing protein 1 (Tiam1) [82].