A study analyzing blood samples from 17 CML patients in the chronic phase and 15 healthy medication-free volunteers found that mature CML CD16 (+) neutrophils had aberrantly increased expression of LTC4 synthase, which might be responsible for stimulating the proliferation of human bone marrow-derived myeloid progenitor cells [97]. The gene discussed is LTC4S; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.