Montelukast and zafirlukast, but not zileuton, significantly inhibited migration and invasion of glioblastoma cells, as well as inhibiting the expression and activities of MMP-2 and MMP-9 in glioblastoma cells and primary human astrocytes, suggesting the important role of CysLT1R in migration and invasion of glioblastoma [80]. The gene discussed is MMP9; the disease is glioblastoma.