In wild-type mice subcutaneously implanted with Lewis lung carcinoma cells, the expression of CysLT2R, but not CysLT1R, was increased in tumor vasculature, while BayCysLT2 (a selective CysLT2R antagonist), but not MK571 (a CysLT1R antagonist), reduced tumor growth, angiogenesis and lung metastasis of tumor cells [90]. This evidence concerns the gene CYSLTR2 and neoplasm.