CYSLTR1 and malignant colon neoplasm: The important role of CysLT1R in colon tumorigenesis was shown in a study using a colitis-associated colon cancer mice model induced by azoxymethane/dextran sulfate sodium, showing higher relative body weight, reduction in inflammation and polyps with lower-grade dysplasia and decreased nuclear expression of β-catenin and COX-2 in mice with global disruption of CYSLTR1 gene expression [92].