In a similar study of CSF from AD patients with similar clinical manifestations, Dangla-Valls et al. (2017) noted increased expression of both miR-125b and miR-222, which, as previously shown, induce phosphorylation of the tau protein by increasing expression of several tau kinases and inhibiting expression of phosphatases [43,44]. The gene discussed is MAPT; the disease is Alzheimer disease.