Characterized in a Henoch-Schönlein purpura rat model, SH2-domain-containing tyrosine phosphatase 2 (SHP2) is another potential modulator of macrophage polarization due to its inhibitory effect on the M2 polarization-promoting STAT3 signaling pathway while also actively inducing M1 polarization. This evidence concerns the gene PTPN11 and Henoch-Schoenlein purpura.