These data suggest that KIAA1217 activates STAT3 and maintains p-STAT3 in the cytoplasm, and then cytoplasmic p-STAT3 subsequently activates the Notch and Wnt/β-catenin pathways, which mediate the effects of KIAA1217 on promoting EMT and invasion and migration of HCC cells (Figure 8E). The gene discussed is KIAA1217; the disease is hepatocellular carcinoma.