Combined application of irinotecan and entinostat synergistically kills CRC cells in vitro and in vivo, and the induction of acetyl-p53-BAK complexes inducing MOMP upon RS C-terminal hyperacetylation of p53 is an absolute requirement for apoptosis induction by irinotecan and entinostat [63]. Here, TP53 is linked to colorectal carcinoma.