The FVBW-17 cell line is the only available murine adenocarcinoma cell line derived from exposure to a tobacco carcinogen, and carries an activating KRASG12D mutation and a mutant TP53 gene [11]; these cells also express EGFR, HER2, HER3, ERβ, and PD-L1 (Supplemental Figure S1). Here, ESR2 is linked to adenocarcinoma.