MiR-155 is also the most upregulated miRNA in microglia and spinal cord tissue of subjects with ALS and SOD1G93A mice, and treatment with anti-miR-155 restored dysfunctional microglia, improved the disease and decreased the recruitment of monocytes in the spinal cord of SOD1 mice [99]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.