In contrast, FBXW7 has been primarily classified as a tumor suppressor gene [51,52] and loss of SCFFBXW7 activity corresponds with aneuploidy, micronucleus formation (extranuclear bodies found outside the primary nucleus and a hallmark of CIN), sister chromatid cohesion defects and chromosome segregation defects (i.e., CIN) [68,93]. This evidence concerns the gene FBXW7 and cervical squamous intraepithelial neoplasia.