As expected, the methylation status of SKP1 varies by cancer type, with SKP1 being hypomethylated (i.e., expressed) in the majority of colorectal, head and neck, ovarian, stomach and uterine cases, whereas it tends to be partially or hypermethylated (i.e., repressed) in bladder, breast, lung and pancreatic cancers. The gene discussed is SKP1; the disease is familial pancreatic carcinoma.