More specifically, the combined frequencies of shallow deletions are 54% (colorectal), 74% (breast) and 84% (lung), while combined frequencies of gains are 55% (breast), 61% (colorectal) and 72% (lung), which suggests that aberrant SCF complex expression (i.e., decreases or increases) may be a significant, yet underappreciated contributor to disease pathology in these cancer types. This evidence concerns the gene KITLG and cancer.