For instance, as aberrant SCF complex function is associated with CIN [9,10,12], developing biomarkers to detect abnormal SCF complex expression could aid early diagnosis in cancers that exhibit high levels of CIN, including colorectal [99] and ovarian cancers [100,101], where early disease detection will be critical to ultimately improve patient outcomes [102,103]. The gene discussed is KITLG; the disease is ovarian carcinoma.