Conversely, other studies have shown that reduced SKP2 expression leads to aberrant increases in P27 abundance that is suggested to prevent mitotic entry and result in increased nuclear areas [2], a CIN-associated phenotype [70,90,91,92] suggestive of large increases in DNA/chromosome content (i.e., polyploidy) [69]. This evidence concerns the gene SKP2 and cervical squamous intraepithelial neoplasia.