CPS1 and cancer: Recently, proteomic analyses of a paclitaxel-resistant, ABCB1 overexpressing, cancer cell model led to the discovery of several novel suspect molecules, particularly ABCC3 (ATP-binding-cassette subfamily C member 3), CPS1 (carbamoyl phosphate synthetase 1), and TRIP6 (thyroid hormone receptor-interacting protein 6) [22,26,27].