These results are not only consistent with those reported in the literature showing that Homer2 participates in the control of ubiquitination and consequent proteolysis via transcriptional downregulation of MuRF1, Atrogin 1, and Myogenin in slow-twitch muscles [17] but also suggest a crucial role of the Homer protein family in the onset of unloading-induced muscle atrophy. This evidence concerns the gene HOMER2 and Atrophy.