In rheumatoid arthritis (RA), synoviocytes express the truncated form of Trx-80, and treatment with the proinflammatory cytokines IL-1β and/or TNF-α increases Trx-80 cell expression, playing an important role in the establishment and/or the development of RA autoimmunity [177]. The gene discussed is IL1B; the disease is rheumatoid arthritis.