LGALS3 and fetal growth restriction: In the placental compartment, lack of galectin-3 compromised placental vascularization and perfusion, resulting in placental insufficiency (reduced placental weight, reduced trophoblast layers, increased pro-inflammatory cytokines expression, reduced placental labyrinth total vessel length and vessel area) and the subsequent development of asymmetric IUGR in mice (as denoted by an increased brain-to-liver weight ratio).