However, in a different study, it was found that macrosomia at birth in pregestational type-1 and type-2 diabetes (PGDM) pregnancies may be predicted by normal levels of galectin-13 together with plasma protein A (PAPP-A), A disintegrin and metalloproteinase 12 (ADAM12) and placental growth factor (PlGF) in the first trimester of pregnancy [119]. The gene discussed is PGF; the disease is Large for gestational age.