Published studies over the last 20 years have validated the finding that forced expression of MDA-7/IL-24, either by transfection of tumor cells with an mda-7/IL-24 cDNA containing plasmid, or by use of a recombinant adenovirus (Ad.mda-7) expressing mda-7/IL-24, significantly inhibits the growth of a diverse spectrum of cancer cells, both in vitro and in vivo in animal models as a single therapeutic [4,5,6,7,16,17,18,19,20,21,55,65]. The gene discussed is IL24; the disease is neoplasm.