With very few exceptions, most normal and cancer cells contain either IL-20R1, IL-20R2 and/or IL-22R1 receptors, which can form dimeric receptor complexes, allowing them to respond to exogenous MDA-7/IL-24 resulting in autocrine induction of MDA-7/IL-24 production, the autocrine/paracrine loop [76]. This evidence concerns the gene IL24 and cancer.