IFNA1 and melanoma: mda-7 was first identified in a human melanoma cell line (HO-1) using a subtraction hybridization technique applied to HO-1 metastatic human melanoma cells irreversibly stimulated to lose their capability of cell division and terminally differentiate after the combination treatment with IFN-ß plus Mezerein (Protein Kinase C activator) [1,2].