IL24 and inflammatory bowel disease: MDA-7/IL-24 expression was also reported at elevated levels in the inflamed mucosal tissue of inflammatory bowel disease patients and similar regulatory mechanisms, i.e., AP-1 and CEBP, mediated activation of the mda-7/IL-24 promoter region due to IL-1ß stimulation in human colonic subepithelial myofibroblast (SEMF) cells [37].