Although, mda-7/IL-24 mRNA is actively expressed in a wide array of human cancers when infected with a replication incompetent Ad expressing mda-7/IL-24 (Ad.mda-7), pancreatic cancer cells display a unique resistance phenotype involving the inability to translate mda-7/IL-24 mRNA into protein [78,79]. The gene discussed is IL24; the disease is familial pancreatic carcinoma.