On the other hand, mutations in various genes including ABCA12, transglutaminase 1 (TGM1), nonimprinted in Prader-Willi/Angelman syndrome-like domain-containing 4 (NIPAL4), 3-lipoxygenase (ALOXE3), 12-lipoxygenase (ALOX12B), CYP4F22, and loci on 12p11.2-q13 are implicated in the pathogenesis of LI and CIE. This evidence concerns the gene TGM1 and congenital non-bullous ichthyosiform erythroderma.