A number of circRNAs, such as circBART2.2, hsa_circ_0136666, circ-keratin 6c, CDR1-AS, circ-VIM, hsa_circ_0003288, CircCHST15, circ-CPA4, hsa-circRNA-002178, and Circ_0000284 were shown to affect PD-L1 expression, leading to tumor immune escape in various types of cancers, including nasopharyngeal carcinoma, colorectal cancer, esophageal cancer, hepatocellular carcinomas (HCC), and lung cancer [13,14,15,16,17,18,19,20,21,22]. Here, CD274 is linked to lung cancer.