JUP and arrhythmogenic cardiomyopathy with wooly hair and keratoderma: Our hypothesis is based on the fact that in two other diseases that are closely related to ACM, Carvajal syndrome and Naxos disease, pathogenic variants in genes encoding desmosomal proteins (JUP and DSP, respectively) present with pathological manifestations in the heart but also in other tissues (skin and hair) [13,14,15].