✓a constitutively active serine/threonine protein kinase composed of two catalytic (α and/or α’) and two regulatory (β) subunits [106,107,108]✓up-regulated in imatinib-resistant CML cells [109]✓Knockdown of α, α’, or β subunit reduces p-RPS6 (S235/236) but not p-AKT (T308/S473) or p-p70S6K (T389) in imatinib-resistant CML cells [109]✓Knockdown of CSNK2A1 (the gene encoding CK2α) or CSNK2B (the gene encoding CK2β) reduces p-RPS6 (S235/236) in an AKT/mTORC1/S6K1-dependent manner in the normal renal tubular epithelial HK-2 cells [110]. This evidence concerns the gene RPS6KB1 and chronic myelogenous leukemia, BCR-ABL1 positive.