✓reduces p-RPS6 (S235/236) in MEFs in a DNA-PK-dependent manner [100]✓induces p-RPS6 (S235/236) in a cervical cancer cell line HeLa by activating S6K1, leading to cisplatin resistance, but not in a lung cancer cell line SiHa [237]. The gene discussed is PRKDC; the disease is cervical carcinoma.