CCNB1 and cancer: ✓an LDHA inhibitor that induces the G2/M cell-cycle arrest via reducing the CDK1/cyclin B1 pathway and promotes apoptosis by enhancing mitochondrial ROS generation in cancer cells [282,283]✓reduces p-RPS6 (235/236) and p-p70S6K (T389) only in glycolysis-dependent cancer cell lines [114]