✓induces p-RPS6 (S240/244) by activating S6K in response to FGFR4 in TNBC MDA-MB-453 cells [112]✓induces p-RPS6 (S240/244) in an HRASG12V head and neck squamous cell carcinoma (HNSCC) cell line by blocking TSC2 to activate the mTORC1 signaling [113]. The gene discussed is TSC2; the disease is head and neck squamous cell carcinoma.