CD274 and non-small cell lung carcinoma: ✓an allosteric inhibitor of AKT1 (IC50 = 5 nM), AKT2 (IC50 = 12 nM), and AKT3 (IC50 = 65 nM) [277]✓reduces p-RPS6 (S235/236) and p-AKT (S473), and induces PD-L1 in an NSCLC cell line HCC827 [150]