✓inhibits p-RPS6 (S240/244) by activating TSC2 via a mechanism dependent on AMPK-priming phosphorylation [96] ✓activated by de-phosphorylation in a 2-DG-dependent manner in glycolysis-dependent cancer cell lines [114]✓induces p-RPS6 through activating S6K1 by directly phosphorylating its S371 residue in HEK293 cells in response to insulin [83]. Here, TSC2 is linked to cancer.