CDKN1A and chronic myelogenous leukemia, BCR-ABL1 positive: ✓an inhibitor of S6K1 (IC50 = 160 nM) [292]✓partially inhibits p-RPS6 in the p21-induced senescent HT-p21 cells [286]✓reduces p-RPS6 (S235/236) in imatinib-resistant CML cells [109]✓reduces p-RPS6 in prostate cancer cell lines PC3 and DU145 with a decrease in cell number and migration only in PC3 cells [293]✓reduces p-RPS6 (S235/236) and induces PD-L1 in H460 and HCC827 NSCLC cell lines [150]