✓a glucose analog widely investigated as a pharmacological agent targeting glycolysis [248]✓reduces p-RPS6 (S240/244) by enhancing the interaction between AMPK and TSC2 [96]✓reduces p-RPS6 (235/236) and p-p70S6K (T389) only in glycolysis-dependent cancer cell lines [114]✓activates AMPK only in glycolysis-dependent cancer cell lines and increases DDIT4/REDD1 [114]. This evidence concerns the gene TSC2 and cancer.