✓induces p-RPS6 (S235/236 and S240/244) through the BCL-ABL/PLCG1/Calmodulin (CALM)/CALM kinase (CAMK)/mTORC1/S6K pathway in parallel with the PI3K/AKT/mTORC1/S6K pathway in CML cells [104]. This evidence concerns the gene PIK3CA and chronic myelogenous leukemia, BCR-ABL1 positive.