✓induces p-RPS6 (S235/236) through the mTORC1-S6K axis, whereas inhibits BRAF activity in rat ELT3 cells [191]✓RHEB-KD downregulates p-RPS6 (S235/236) in MCF7 cells [115]✓enhances mTORC1 substrate recognition via increasing RPTOR binding [192,193]✓restores 2-DG-ablated p-RPS6 (S235/236 and S240/244) and p-p70S6K (T389) in a glycolysis-dependent cancer cell line [114]. The gene discussed is BRAF; the disease is cancer.