✓an allosteric mTOR inhibitor (IC50 = ~0.1 nM) [300]✓inhibits the serum-induced increase in p-RPS6 and translation of TOP mRNAs in Swiss mouse 3T3 cells [93]✓inhibits p-RPS6 (S235/236, S240/244) via S6K1 [48,301]✓inhibits p-RPS6 in p21-induced senescent HT-p21 cells [286] ✓inhibits human CG- and forskolin-induced p-RPS6 (S235/236) [82]✓reduces p-RPS6 levels that induced by PD-L1 Ig [149]✓upregulates PDCD4 in BCR-ABL CML cells but downregulates p-RPS6 (S235/236) and p-p70S6K (T389) [103]. This evidence concerns the gene CDKN1A and chronic myelogenous leukemia, BCR-ABL1 positive.