CD274 and non-small cell lung carcinoma: ✓an inhibitor of PI3K p110α (IC50 = 52 nM), p110δ (IC50 = 116 nM), p110β (IC50 = 166 nM), and p110γ (IC50 = 262 nM) [230]✓reduces p-RPS6 (S235/236), but not p-AKT (S473), and induces PD-L1 in an NSCLC cell line HCC827 [150]