✓an allosteric mTOR inhibitor of FKBP12 (IC50 = 1.6–2.4 nM) [253]✓reduces p-RPS6 (S235/236 and S240/244) in leukemia cells [104]✓reduces p-RPS6 in bladder cancer cells [118]. The gene discussed is RPS6; the disease is urinary bladder cancer.