✓an inhibitor of mTORC1 (IC50 = 2 nM), DNA-PK (IC50 = 6.34 nM), and mTORC2 (IC50 = 10 nM) [312,313]✓reduces p-RPS6 (S235/236) and p-AKT (S473), and induces PD-L1 in an NSCLC cell line, HCC827 [150]. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.