✓an inhibitor of IGF1R (IC50 = 35 nM), INSR (IC50 = 75 nM), and insulin receptor-related protein (IRR) (IC50 = 75 nM) [266]✓induces p-RPS6 in CRC cells through activation of p70S6K1, which is inactivated by PDCD4 [188]. This evidence concerns the gene RPS6KB1 and colorectal carcinoma.