✓an MEK1 inhibitor (IC50 = 14 nM) [307]✓reduces p-RPS6 (S235/235) in vemurafenib-sensitive melanoma cells, but not in resistance melanoma cells [308]✓synergistically reduces p-RPS6 (S235/235) with RICTOR-KD or S6K1/2-KD in vemurafenib-resistance melanoma cells [308]. The gene discussed is MAP2K1; the disease is melanoma.