RPS6KB1 and cancer: ✓a selective inhibitor of glutaminase kidney isoform GLS1 (IC50 = 0.16 μM) [229]✓modestly reduces p-RPS6 (235/236) and p-p70S6K (T389) and synergizes with 2-DG to ablate p-RPS6 (235/236) and p-p70S6K (T389) in glycolysis-independent cancer cell lines [114]