✓inhibits ATM (IC50 = 0.2 mM), mTOR (IC50 = 0.4 mM), ATR (IC50 = 1.1 mM), CHEK1 (IC50 = ~5 mM), and DNA-PKcs (IC50 = ~10 mM) [234]✓reduces p-RPS6 (S235/236) through the PI3K/AKT/mTOR/S6K pathway in neuroblastoma cells [235]. The gene discussed is PIK3CA; the disease is neuroblastoma.