✓the last enzyme of de novo purine synthesis, which transfers a formyl group to AICAR to produce the intermediate formyl-AICAR and inositol monophosphate (IMP) [164]✓ATIC-KD inhibits p-RPS6 (S235/236), p-p70S6K (T389), and p-mTOR (S2448) through activation of AMPK in hepatocellular carcinoma cell lines [165]. The gene discussed is RPS6KB1; the disease is hepatocellular carcinoma.