✓a potent inhibitor of PIM1 (IC = 0.4 nM), PIM3 (IC = 1.9 nM), and PIM2 (IC = 5 nM) [224]✓downregulates p-RPS6 (S235/236) and p-mTOR (S2448) but upregulates p-eIF2α (S51), p-AMPK (T172), and p-LKB1 (S428) in the human liposarcoma cell line 93T449 [215]. The gene discussed is PIM3; the disease is liposarcoma.