✓Knockdown of PIK3CA (the gene encoding p110α), but not PIK3CB (the gene encoding p110β), reduces p-RPS6 (S235/236 and S240/244) and p-AKT (S473) in the small cell lung cancer cell (SCLC) line, H69 and concomitantly reduces the cell viability [131]. This evidence concerns the gene AKT1 and small cell lung carcinoma.