✓a tumor suppressor that negatively regulates AKT and S6K1 [134], and PKC [135] through direct dephosphorylation✓Loss of PHLPP upregulates p-RPS6 (S235/236) and the amount of p-RPS6 bound to the translation initiation complex via activating S6K1 in response to insulin, leading to increases in cell size, protein content, and rate of cap-dependent translation [134]✓activated by mTORC1 in response to glucose or amino acids in colon and breast cancer cells [67]. The gene discussed is PHLPP1; the disease is neoplasm.