✓a tumor suppressor, acting as a dual-specificity protein phosphatase that dephosphorylates tyrosine-, serine- and threonine-phosphorylated proteins [138]✓Loss of PTEN resulted in upregulation of p-RPS6 (S235/236) through activation of the AKT/mTOR pathway [139]✓Pten-KD induces p-RPS6 (S240/244) in rat cortical neuron [140]. This evidence concerns the gene PTEN and neoplasm.