✓absent in healthy adult exocrine pancreas but ectopically expressed in pancreatic ductal adenocarcinoma [174,175,176]✓PLAC8-KD downregulates p-RPS6 (S235/236) and p-RB (S807/811) in human BON-1 pancreatic neuroendocrine tumor cells [177]. The gene discussed is RPS6; the disease is pancreatic ductal adenocarcinoma.