✓an inhibitor for PI3K p110α (IC50 = 2 nM), p110β (IC50 = 3 nM), p110δ (IC50 = 3 nM), p110γ (IC50 = 15 nM), DNA-PK (IC50 = 23 nM), and mTOR (IC50 = 30 nM) [288]✓reduces p-RPS6 (S235/236, S240/244) and p-AKT (S473) in an SCLC cell line, H69 [131]✓reduces p-RPS6 (S235/236), p-mTOR (S2448), p-AKT (S473), p-GSK3β (S9), and p-BAD (S112) in TNBC cells [289]. This evidence concerns the gene PRKDC and small cell lung carcinoma.