AKT1 and Familial prostate cancer: ✓a competitive non-selective inhibitor of beta-adrenergic receptors (IC50 = 12 nM) [297]✓inhibits LPIN activity [179,298,299]✓inhibits p-AKT (S473) and p-RPS6 (S235/236) and induces accumulation of LC3-II and p62 in the prostate cancer cell line PC3, and sensitizes PC3 and HS578T to rapamycin [183]