RPS6 and melanoma: ✓an inhibitor of PI3Kα (Ki = 0.019 nM), PI3Kδ (Ki = 0.024 nM), PI3Kγ (Ki = 0.06 nM), PI3Kβ (Ki = 0.13 nM), mTORC1 (Ki = 0.18 nM), and mTORC2 (Ki = 0.3 nM) [281]✓reduces p-RPS6 in melanoma cells with acquired resistance to dabrafenib in combination with dabrafenib and trametinib (GSK1120212) [243]