✓a PI3K and mTOR inhibitor (IC50 value for p110α, p110γ, mTOR (p70S6K), p110δ, ATR, p110β is 4, 5, 6, 7, 21, 75 nM, respectively) [244,245]✓reduces p-RPS6 in bladder cancer cells [118]✓reduces p-RPS6 (S235/236) and p-AKT (S473) and induces PD-L1 in an NSCLC cell line HCC827 [150]. This evidence concerns the gene ATR and urinary bladder carcinoma.