✓a specific inhibitor for DNA-PK (IC50 = 2 nM), PI3K p110α (IC50 = 5.8 nM), and PI3K p110γ (IC50 = 76 nM) [290,291]✓reduces p-RPS6 (S235/236 and S240/244) and p-AKT (S473) in the SCLC cell line H69 and concurrently reduces the cell viability by inducing apoptosis and autophagy [131]. This evidence concerns the gene PIK3CA and small cell lung carcinoma.