RPS6KB1 and cancer: ✓a potent, selective, and orally bioavailable glutaminase inhibitor (IC50 = 24 nM), having antitumor activity in TNBC cells [236]✓modestly reduces p-RPS6 (235/236) and p-p70S6K (T389) and synergizes with 2-DG to ablate p-RPS6 (235/236) and p-p70S6K (T389) in glycolysis-independent cancer cell lines [114]