✓induces p-RPS6 (S235/236) by inhibiting TSC2 via TSC2 phosphorylation at S1798 in multiple myeloma (MM) cells [132]✓identified as a p-RPS6 (S235/236) regulator in MIA PaCa-2 cells [79]✓Knockdown of PIM2, but not PIM1, reduces p-RPS6 (S235/236) and p-p70S6K (T389) in glioblastoma multiforme (GBM) LN229 cells [133]. The gene discussed is TSC2; the disease is AL amyloidosis.