IGF1R and colorectal cancer: Programmed cell death 4 (PDCD4) was reported to downregulate p70S6K1 phosphorylation and translation, but not p70S6K2, leading to chemosensitivity of colorectal cancer (CRC) cells to the insulin-like growth factor 1 receptor (IGF1R) inhibitor linsitinib (OSI-906) [103].