✓reduces p-RPS6 (S240/244) by inhibiting mTORC1 through TSC2 phosphorylation [96]✓a constitutively active mutant AMPKα reduces p-RPS6 (S235/236) in the colorectal cancer (CRC) cell line HT-29 [105]✓activated by PGC-1β overexpression, leading to upregulation of p-RPTOR (S792) and p-RPS6 (S240/244) in MDA-MB-231 cells [101]. The gene discussed is TSC2; the disease is colorectal carcinoma.