✓an inhibitor of insulin receptor (INSR) (IC50 = 1.8 nM), IGF1R (IC50 = 1.8 nM), TRKB (IC50 = 4.1 nM), MET (IC50 = 5.6 nM), TRKA (IC50 = 7.4 nM), AURKA (IC50 = 9 nM), AURKB (IC50 = 25 nM), and RON (IC50 = 44 nM) [228]✓induces p-RPS6 by activating p70S6K1 and MEK1/2 in HCT116 CRC cells [188,189]. The gene discussed is MAP2K1; the disease is colorectal carcinoma.