RPS6 and familial pancreatic carcinoma: For example, a genome-scale siRNA screening against 21,121 genes revealed multiple regulators for p-RPS6 (S235/236) in the pancreatic cancer cell line MIA PaCa-2, which contains a constitutively high p-RPS6 level, followed by confirmation in TSC1-null mouse embryonic fibroblasts (MEFs) [79].