✓an inhibitor of PIM1 (IC50 = 7 nM), FLT3 (IC50 = 44 nM), PIM3 (IC50 = 69 nM), and PIM2 (IC50 = 363 nM) [309]✓reduces p-RPS6 (S235/236) and p-70S6K (T389) in GBM LN229 cells [133]✓synergistically reduces p-RPS6 (S235/236) with alpelisib (BYL-719) in LN229 and U87 GBM cells and 83Me GBM mesenchymal stem cells, leading to synergistic inhibition of cell viability [133]. Here, PIM3 is linked to glioblastoma.