A meta-analysis of the genetic association studies regarding patients with DN revealed the significance of variants in CCL2, CCR5, IL6, IL8, EPO, IL1A, IL1B, IL100, IL1RN, GHRL, MMP9, TGFB1, VEGFA, MMP3, MMP12, IL12RB1, PRKCE, TNF, and TNFRSF19 genes in the development of DN [5]. This evidence concerns the gene CXCL8 and liver dysplastic nodule.