The protein network analysis by the CytoHubba plugin revealed the following 10 genes as the nodes with the most interactions in T1DM-DN: EP300, RPS11, RPS5, RPS23, RPS9, GRB2, RPS15A, NHP2L1, CCNB1, and RPL3 (Table 5 and Figure 4). The gene discussed is GRB2; the disease is type 1 diabetes mellitus.