A meta-analysis of the genetic association studies regarding patients with DN revealed the significance of variants in CCL2, CCR5, IL6, IL8, EPO, IL1A, IL1B, IL100, IL1RN, GHRL, MMP9, TGFB1, VEGFA, MMP3, MMP12, IL12RB1, PRKCE, TNF, and TNFRSF19 genes in the development of DN [5]. The gene discussed is IL1B; the disease is liver dysplastic nodule.