In T2DM, the 10 genes with the most interactions in the protein network are: IL6, ACTB, MAPK1, RAC1, CYCS, CXCL8 (IL8), SNRPD3, CSF2, RPL9, and HSPA4 (Table 5) (Figure 5). The gene discussed is ACTB; the disease is type 2 diabetes mellitus.