In the brain of late-onset AD patients with Braak stage IV-VI pathology, obtained post mortem, there are no differences in 5mC or 5hmC levels in AD-resistant calretinin interneurons or microglia, nor any differences near β-amyloid plaque regions of interest, nor in plaque-free zones [67,68]. The gene discussed is CALB2; the disease is Alzheimer disease.