For patients with NDD-PD, we calculated AUC values of 0.84 for SIRT activity (Youden index 0.66; 81.25% specificity, 85% sensitivity) and 0.95 for BDNF expression (Youden index 0.66; 100% specificity and 60% sensitivity). The gene discussed is BDNF; the disease is Parkinson disease.