Some other molecules were also determined as markers for EVs (14-3-3 proteins, MHC molecules, stress proteins (HSP), tumor susceptibility gene 101 (TSG101) and ESCRT-3 binding protein ALIX [19]), but CD63 and TSG101 were observed in all EV groups in a comprehensive cancer study showing different distributions based on their appearance and origin [20]. The gene discussed is CD63; the disease is cancer.