In previous studies in Japan, six more loci were associated with AF: at 1q24 in PRRX1 (rs593479), 4q25 near PITX2 (rs2634073), 7q31 in CAV1 (rs1177384), 10q25 in NURL1 (rs6584555), 12q24 in CUX2 (rs649002), and 16q22 in ZFHX3 (rs12932445) [95]. The gene discussed is CAV1; the disease is atrial fibrillation.