In this study, we explored Microarray Data Extraction and predicted overexpressed and downregulated genes in GBM tumors; moreover, we utilized online prediction tools to further identify and validate expressions of our genes of interest, the CCNB1/MAPK7/CDC42/CD44 oncogenes and also predicted patients’ clinical outcomes in GBM under the same settings. The gene discussed is CCNB1; the disease is glioblastoma.