Additionally, IFN-γ production by Th1 cells induces secretion of CXCL9 and CXCL10 by tumor-associated macrophages (TAM) and cancer-associated fibroblasts (CAF) as well as tumor cells present in the TME that promote tumor-effector T cell infiltration in melanoma patients [21,22]. This evidence concerns the gene CXCL9 and neoplasm.