AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive: Several signaling pathways were significantly enriched for underexpressed genes (Figure 3, FDR-adjusted p-value ≤ 0.05, accelerated vs. chronic: cytokine receptor interaction; blast vs. accelerated: MAPK signaling, adherens junction; blast vs. chronic: MAPK signaling, PI3K-Akt signaling, VEGF signaling), but no enrichment of overexpressed genes was observed for an individual pathway for the comparisons of the three CML phases.