Few well-researched oncogene mediated phenotypic changes have been identified in the immune cell compartment; for example, in kras (Kirsten rat sarcoma virus) mutant-induced pancreatic ductal cell adenocarcinoma (PDAC), tumor cells secreting increased levels of cytokines such as of GM-CSF, actively increasing the infiltration of immunosuppressive Gr-1− CD11b+ myeloid cells and decreasing the T cell-mediated killing of cancer cells [10]. The gene discussed is KRAS; the disease is neoplasm.