LDHA and lung adenocarcinoma: In research conducted by Hou et al., they identified knocking down the ldha gene using LDHA siRNA in a lung adenocarcinoma (LUAD) cell line resulting in down regulation of epithelial markers such as vimentin and snail, while upregulating E-Cadherin, indicating a role of LDHA in epithelial to mesenchymal transition (EMT) [24].