For example, genes encoding the retinoblastoma tumor suppressor (RB1), cell cycle inhibitors p16INK4a (CDKN2A) and p15INK4a (CDKN2B), mismatch repair factor MLH1, inhibitory molecules for cancer invasion and metastasis such as E-cadherin (CDH1) and H-cadherin (CDH13), the apoptosis signal regulator DAPK1, and various transcription factors involved in tumor suppression are negatively regulated by DNA hypermethylation in cancer [65]. The gene discussed is RB1; the disease is cancer.