In breast cancer cells, loss of O-GlcNAcylation on Ser-108 of cofilin results in destabilization of invadopodia and impairs cancer cell invasion [19], and O-GlcNAcylation on Ser-408 of TAK1 binding protein 3 (TAB3) contributes to TAB3-mediated promotion of cancer cell migration and invasion by activating NF-ĸB [20]. This evidence concerns the gene TAB3 and cancer.