A similar consideration can be made for the entry of glutamine-derived glutamate in mitochondria of CRC cells, where glutamate enters the matrix mainly through GC1 [71]; the Km of GC1 for glutamate is 5.18 mM [31] which is about thirty fold higher than that of AGCs (0.21 mM) [76]. The gene discussed is SLC25A22; the disease is colorectal carcinoma.