CD4 and cancer: By calculating the relationship between the immunocyte composition and the gene expression in immunotherapy responders, the proportions of CD4 T cells, CD8 T cells, DC cells, macrophages, and NK cells were positively correlated with the expression of CASP1, NLRP1, NLRP3, PYCARD, and IRF2, respectively, in most cancers (Figure 6E).