Indeed, proteomics studies available on the Vesiclepedia database demonstrate that distinct proteins involved in autophagy were found in melanoma EVs by different groups (Table 1), including the ones mentioned above as regulators of secretory autophagy (ATG7, GRASP, RAB8A, SEC22, STX3/4, and SNAP23/29) (Figure 1). This evidence concerns the gene SNAP23 and melanoma.