For instance, the secretion of different cytokines, such as VEGF-A and IL-8 by melanoma cells, trigger pro-angiogenic signaling in surrounding endothelial cells and prompting an angiogenesis switch, which is correlated with the transition of melanocytic lesions to vertical growth phase—a stage with a higher capacity to metastasize [17,56,57]. The gene discussed is CXCL8; the disease is melanoma.