Moreover, in hepatocarcinoma (Huh7) and cervical adenocarcinoma (HeLa) cells, siRNA-mediated knockdown of AGPAT2 as well as inhibition of AGPAT2 induction by HIF-1α silencing interfere with TAG and phospholipid synthesis and prevents lipid droplet accumulation under hypoxia, resulting in a decrease of viability and increase of cancer cell sensitivity to the chemotherapeutic etoposide [27]. Here, AGPAT2 is linked to cancer.