In particular, docosahexaenoic acid, the omega-3 PUFA, has also been reported to reduce the HCC cell growth through inhibition of the signal transduction of prostaglandin E2 by downregulating COX-2 and upregulating 15-hydroxyprostaglandin dehydrogenase, a COX-2 antagonist [37]. This evidence concerns the gene HPGD and hepatocellular carcinoma.