Recent evidence suggests that miR-148b deficiency promotes HCC growth and metastasis through colony-stimulating factor-1 (M-CSF)/CSF1 receptor (CSF1R)-mediated TAM infiltration, while HCC patients with decreased miR-148b levels and increased TAM infiltration were correlated with worse prognosis [97]. This evidence concerns the gene CSF1 and hepatocellular carcinoma.