MRC1 and hepatocellular carcinoma: Another study by Zhu et al. revealed that CD206 was highly expressed in the HCC tissues compared to its peri-carcinoma tissue levels, while GdCl3 treatment suppressed the malignant potential of HCC in vitro and in vivo, mainly by downregulating the expression of CD206 in M2 macrophages, indicating the potential significance of CD206 as a biomarker for HCC prognosis [104].