In this context, we previously reported that FoxO3a overexpression reduces motility, invasiveness, and anchorage-independent growth in ERα+ BC cells (BCCs) while leading to opposite effects in cells lacking ERα and that nuclear FoxO3a is inversely or directly correlated with the invasive phenotype of ERα+ or ERα− breast tumors, respectively [22]. Here, ESR1 is linked to breast neoplasm.