In the Kaplan–Meier analysis, none of the following risk factors were significant: type of LN involvement (MAC, MIC, ITC), histological tumor type, tumoral diameter, LVSI identified by H/E or D2-40, VEGF-C, Ki-67 or CD-31, and the age of the patients correlated with lower survival (Table 5). The gene discussed is VEGFC; the disease is neoplasm.