In the multicentric prospective clinicopathological study named MICROCOL, we aimed to assess whether known markers of cancer cell proliferation (Ki-67), tumor angiogenesis (CD31), and lymphangiogenesis (VEGF-C and D2-40) were associated with an increased risk of PLNM, including low-volume metastasis (MIC and ITC), in a cohort of women with early-stage cervical cancer. This evidence concerns the gene PECAM1 and cervical cancer.