CD8A and neoplasm: Additionally, when the presence of CD4+ T cells was taken into consideration, the CD4+LAIR2+ TILs signature gained greater significance within each dataset, TCGA (HR = 1.54; p = 0.0045, Figure S5A) and DCC (HR = 1.37; p = 0.018, Figure S5C), which was not observed when normalized to CD8+ T cells (Figure S5B,D), confirming the association between LAIR2 expression and presence of CD4+ tumor-associated Treg cells.