CD4+LAIR2+ cells highly expressed Treg cell lineage markers, including IL2RA, CTLA4, TNFRSF18, ICOS, TIGIT, and tumor-associated Treg cell marker CCR8 [18] (Figure 4D, right panel; Figure S3B), consistent with CD4+ LAIR2+ cells being of Treg lineage and not recently activated T cells. Here, ICOS is linked to neoplasm.